POS0093 ASSESSMENT OF HISTOLOGICAL FEATURES OF CHRONICITY OF MINOR SALIVARY GLAND BIOPSY IN PATIENTS WITH PRIMARY SJOGREN’S SYNDROME

Background The origin of the histological chronic inflammation salivary gland in patients with primary Sjogren’s Syndrome (pSS) is questionable. It probably a consequence both, evolution disease itself and ageing Objectives This study aims to evaluate data chronicity minor biopsy clinical characteristics time series pSS. Methods A cross-sectional including 98 subjects fulfilling ACR-EULAR 2017 classification criteria for All underwent requested as per practice. We collected age at diagnosis biopsy, xeroftalmia xerostomia time, stimulated unstimulated flow data. informed following features biopsy: focus score (positive if ≥ 1), atrophy, fibrosis adiposity all graded negative, mild, moderate, severe stages according pathological criteria. Results included median recruited parameters are shown Table 1. Only 2 presented adiposity, so we did not consider them analysis. Both, significantly higher between none, mild moderate three parameters. increased stages, median, 10, 9 6 years respectively. Although more observed atrophy regarding categories, it does reach statistical signification. Focus associated high percentage stage shows negative (78% vs 22%, p = 0.046) while display positive (61%, 73% 64%, respectively). Furthermore, observe significant OR 8.75 [1.7-68] [1.25-44] 9.92 [1.8-80] compared atrophy. Fibrosis related score. low although differences explained when (3.5 1.4 3 1.75 fibrosis). Regarding lineal statistically association every (3.5, 1.65 0.7, p< 0.001). No shown. Description variables study. Categories N(%)Median(IQR) Age diagnosis(years) 55.220 (51.097, 58.407) (years) 57.719 (53.851, 61.333) Xerostomia (months) 19.614 (10.480, 35.121) Xeroftalmia 21.487 (8.148, 38.735) (positive) 63 (64.3%) USF (ml/15 min) 2.000 (1.400, 3.000) SSF (ml/ 5min) 4.500 (3.000, 5.000) Atrophy Negative 28 (28.7%) Mild 37 (38.1%) Moderate 23 (23.7%) Severe (9.3%) 29 (30.5%) 40 (42.1%) 26 (27.4%) Adiposity 39 (41.1%) 38 (40%) 18 (18.9%) USF: Unstimulated flow, SSF: Stimulated Conclusion An older fibrosis, adiposity. Patient less score, which might be noticed interpretation Disclosure Interests None declared